| ORIGINAL ARTICLES |
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| Year : 2022 | Volume
: 2
| Issue : 1 | Page : 15-22 |
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Hypoglycemic and antihyperlipidemic effects of hydroalcoholic extract of maize silk on dexamethasone-induced-hyperglycemic rats
Barnabé Lucien Nkono Ya Nkono1, Rouamba Ablassé2, Mc Jesus Kinyok3, Soumiatou Nzikoué1, Léocadie Mbella Kédi1, Placide Yannick Amougou Noa1, Paul Désiré Djomeni Dzeufiet4, Sélestin Dongmo Sokeng5, Pierre Kamtchouing4
1 Department of Biological Sciences, Higher Teacher Training College, University of Yaoundé I, Yaoundé, Cameroon
2 Department of Chemistry, Laboratory of Applied Biochemistry and Chemistry, University Joseph KI-ZERBO, Ouagadougou, Burkina Faso
3 Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, Yaoundé, Cameroon
4 Department of Animal Biology and Physiology, Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroon
5 Department of Biological Sciences, Faculty of Sciences, University of Ngaoundéré, Ngaoundéré, Cameroon
Correspondence Address:
Barnabé Lucien Nkono Ya Nkono
Department of Biological Sciences, Higher Teacher Training College, University of Yaoundé I, PO Box 8201 Yaoundé
Cameroon
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/JCDM.JCDM_16_21
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Context: Maize silk (Zea mays) is used in traditional medicine to treat high blood pressure, diabetes and obesity. It is also used as an immunostimulant but few scientific studies are available to validate these properties. Aims: The aim of this study was to scientifically validate the traditional use of maize silk in the regularization of lipid profile and blood glucose level. Material and Methods: Hydroalcoholic extract of maize silk (HAEMS) was prepared by decoction (30:70 Water-Ethanol) from the dry powder of corn silk (250 g/L). Hyperglycemia was induced by repeated single daily subcutaneous injection (s.c) of dexamethasone (5 mg/kg); dexamethasone negative control group (DNC) received dexamethasone exclusively throughout 14 days while negative normal control group (NNC) received only vehicle during the same period. Positive control group (glibenclamide) and plant extract groups (50 and 100 mg/kg) received dexamethasone from the eighth day and each group consisted of six animals. All the parameters (fasting blood glucose level, TC, HDL, LDL, VLDL, atherogenic index (AI) and TG) were measured on the first, seventh and fourteenth day of the experiment. Lipid profile was performed using a BIOLABO® Kit and fasting blood glucose level was measured using a glucometer VivaCheck™ Ino. Results: Compared to the DNC group, HAEMS significantly reduced (P<0.001) on days seven and fourteen, fasting blood glucose level, TC, LDL, VLDL, artherogenic AI and TG (on day seven). In addition, only the dose of 50 mg/kg significantly increased serum HDL on the seventh (P<0.01) and fourteenth day (P<0.001). Conclusion: The results obtained in this study suggest that HAEMS have hypoglycemic and antihyperlipidemic properties. |
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